Important: Therapy
Amoxicillin oral 1g 8 hourly
Or
Doxycycline oral 200mg stat on first day then 100mg daily
Duration 5 days then review
Change to 1g amoxicillin PO dose
Sampling note added for CURB2
Dependant on severity
Amoxicillin oral 1g 8 hourly
Or
Doxycycline oral 200mg stat on first day then 100mg daily
Duration 5 days then review
Amoxicillin oral 1g 8 hourly
Use IV if oral route unavailable.
Switch to oral antibiotics as soon as clinically appropriate
If penicillin allergy,
Doxycycline oral 200mg stat on first day then 100mg daily
Or
Clarithromycin oral 500mg 12 hourly (IV if oral route unavailable)
If Legionella, Mycoplasma or other atypical bacterial pathogens suspected, add clarithromycin oral 500mg 12 hourly (IV if no oral route)
Send urine sample for Legionella antigen and throat swab for mycoplasma.
Duration 5 days then review
Co-amoxiclav IV 1.2g 8 hourly
+
Clarithromycin oral or IV 500mg 12 hourly
If penicillin allergy
Levofloxacin oral or IV 500mg 12 hourly
Total duration 5 days then review.
May need to be extended to 14-21 days according to clinical judgement e.g. if suspected/confirmed “atypical” pathogen, Legionella, Staphylococcal or Gram negative bacilli.
Community Acquired Pneumonia
Assess CURB-65 score.
Consider sending throat swab in viral transport medium for viral studies and urine in white-topped universal for Legionella antigen.
Fluroquinolones
Refer to important safety information for all quinolones prior to prescribing.
See MHRA Drug Safety Update January 2024: Fluoroquinolones must only be used in situations when other antibiotics, that are commonly recommended for the infection, are inappropriate such as: