Antimicrobial prescribing: NHS Borders
Flucloxacillin IV 2g 6 hourly
+
Ciprofloxacin IV 400mg 12 hourly (IV for first dose then review if appropriate to switch patient to oral)
+
Metronidazole IV 500mg 8 hourly or, if oral route available, 400mg oral 8 hourly
Fournier Gangrene/Perineal Cellulitis
Warning
Surgical treatment is the definitive treatment for Fournier’s gangrene – antibiotics are an adjunct.
Fluroquinolones
Refer to important safety information for all quinolones prior to prescribing.
See MHRA Drug Safety Update January 2024: Fluoroquinolones must only be used in situations when other antibiotics, that are commonly recommended for the infection, are inappropriate such as:
- there is resistance to other first-line antibiotics recommended for the infection
- other first-line antibiotics are contraindicated in an individual patient
- other first-line antibiotics have caused side effects in the patient requiring treatment to be stopped
- treatment with other first-line antibiotics has failed
Vancomycin (according to vancomycin dosing guideline)
+
Ciprofloxacin IV 400mg 12 hourly (IV for first dose then review if appropriate to switch patient to oral)
+
Metronidazole IV 500mg 8 hourly or, if oral route available, 400mg oral 8 hourly