Link updated.
Sepsis of Unknown Source
If the source of infection is known, antimicrobial therapy can be based on the most suitable empirical therapy for the infection, pending results of culture and susceptibility tests.
If source is unknown, take appropriate samples of specific body fluids, e.g. urine, sputum to determine the source of infection.
Change according to results of sensitivities. Switch to oral as soon as appropriate.
Amoxicillin 1g IV 8 hourly
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Gentamicin IV. (Use NHS Borders Gentamicin Calculator). Max 3 days then review.
If MRSA suspected, substitute Vancomycin IV (Use NHS Borders Vancomycin calculator) for amoxicillin.
If intra-abdominal source suspected see Gastro-Intestinal Tract Infections – Intra-Abdominal Sepsis
Change according to results of sensitivities. Switch to oral as soon as appropriate.
Vancomycin IV (Use NHS Borders Vancomycin calculator)
+
Gentamicin IV Use NHS Borders Gentamicin Calculator. Max 3 days then review
If intra-abdominal source suspected see Gastro-Intestinal Tract Infections – Intra-Abdominal Sepsis
Change according to results of sensitivities. Switch to oral as soon as appropriate.
Antimicrobial prescribing: NHS Borders