Co-amoxiclav IV
or if Penicillin allergy
Teicoplanin IV
+
Gentamicin IV
NHS Borders Emergency Department Antibiotic Management in Bomb Blast/Explosive Injuries
This guidance is adapted from Public Health England guidance (issued May 2017) and NHS Greater Glasgow and Clyde guidance (issued May 2019) and is intended for ED use. Further advice on ongoing antibiotic management may be provided by microbiology if required. In addition to antibiotics, tetanus and BBV exposure should be considered:
Tetanus prophylaxis
ALL bomb blast victims with injuries must have their tetanus immunisation status checked and treated according to the extant advice on management of patients with tetanus prone wounds in the ‘Green Book’.
Blood-borne virus prophylaxis
ALL patients who sustained injuries that breached skin must receive an accelerated course of Hepatitis B vaccination.
Patients who are discharged from inpatient care before completion of an accelerated hepatitis B vaccination course should receive remaining doses of vaccine via NHS Borders Vaccination Service Hub.
ALL patients should be tested at 3 months to determine their hepatitis B vaccine response and at 3 months and 6 months to determine their hepatitis C and HIV status.
Post exposure prophylaxis for HIV- HIV PEP is not usually required. Discuss with GUM/RIDU Consultant on call if uncertain.
Co-amoxiclav IV
or if Penicillin allergy
Teicoplanin IV
+
Gentamicin IV
Co-amoxiclav IV
or if Penicillin allergy
Teicoplanin IV
+
Gentamicin IV
Ceftriaxone* IV
+
Metronidazole IV
or, if convincing severe Penicillin allergy
Teicoplanin IV
+
Gentamicin IV
+
Metronidazole IV
Ceftriaxone* IV
or, if convincing severe Penicillin allergy
Teicoplanin IV
+
Gentamicin IV
No antibiotics indicated
Give Pneumovax
IV route only if unable to swallow
Ciprofloxacin PO/IV
+
Clindamycin PO/IV
+
Topical Chloramphenicol
Co-amoxiclav IV
or if Penicillin allergy
Teicoplanin IV
+
Gentamicin IV
If perforation and spillage of gastrointestinal contents or oesophageal perforation
Add Fluconazole IV
*in neonates, see cautions/contra-indications in BNF for Children. An alternative is Cefotaxime.