Antibiotic Management in Bomb Blast / Explosive Injuries

Warning

NHS Borders Emergency Department Antibiotic Management in Bomb Blast/Explosive Injuries

This guidance is adapted from Public Health England guidance (issued May 2017) and NHS Greater Glasgow and Clyde guidance (issued May 2019) and is intended for ED use. Further advice on ongoing antibiotic management may be provided by microbiology if required. In addition to antibiotics, tetanus and BBV exposure should be considered:

Tetanus prophylaxis

ALL bomb blast victims with injuries must have their tetanus immunisation status checked and treated according to the extant advice on management of patients with tetanus prone wounds in the ‘Green Book’.

Blood-borne virus prophylaxis

ALL patients who sustained injuries that breached skin must receive an accelerated course of Hepatitis B vaccination.

Patients who are discharged from inpatient care before completion of an accelerated hepatitis B vaccination course should receive remaining doses of vaccine via NHS Borders Vaccination Service Hub.

ALL patients should be tested at 3 months to determine their hepatitis B vaccine response and at 3 months and 6 months to determine their hepatitis C and HIV status.

Post exposure prophylaxis for HIV- HIV PEP is not usually required. Discuss with GUM/RIDU Consultant on call if uncertain.

 

Soft Tissue Injury +/- Foreign body in situ

Co-amoxiclav  IV

or if Penicillin allergy

Teicoplanin IV

+

Gentamicin IV

Open fractures/“through and through fractures”/Intra-articular injuries

Co-amoxiclav IV

or if Penicillin allergy

Teicoplanin IV

+

Gentamicin IV

Penetrating CNS injury (or multiple penetrating injuries including CNS)

Ceftriaxone* IV

+

Metronidazole  IV

or, if convincing severe Penicillin allergy

Teicoplanin IV

+

Gentamicin IV

+

Metronidazole IV

Open skull fracture (No CNS injury)

Ceftriaxone* IV

or, if convincing severe Penicillin allergy

Teicoplanin IV

+

Gentamicin IV

CSF leak post-skull fracture

No antibiotics indicated

Give Pneumovax

Penetrating eye injuries

IV route only if unable to swallow

Ciprofloxacin PO/IV

+

Clindamycin PO/IV

+

Topical Chloramphenicol 

Penetrating abdominal/ thoracic wound

Co-amoxiclav IV

or if Penicillin allergy

Teicoplanin IV

+

Gentamicin IV

If perforation and spillage of gastrointestinal contents or oesophageal perforation

Add Fluconazole IV

 *in neonates, see cautions/contra-indications in BNF for Children. An alternative is Cefotaxime.

Editorial Information

Last reviewed: 15/04/2025

Next review date: 01/05/2028

Author(s): Duguid, A, James, E, Taylor, J, McCarthy, C.

Version: 5.0

Approved By: NHS Borders Antimicrobial Management Team

Reviewer name(s): Duguid, A, James, E.