Warning

Clinical features

  • Hot, swollen, painful joint
  • Fever and systemic upset

Investigations

  • Blood culture
  • Joint aspirate for culture

Infection Control

Basic universal precautions

Treatment

Source control is essential – discuss with Orthopaedics

Prosthetic joint infection may require debridement or removal of prosthesis

FLUCLOXACILLIN IV 2g 6 hourly

 

If true penicillin allergy or known MRSA:

VANCOMYCIN IV Dose as per calculator

Target trough 15-20 mg / L

Duration: Discuss with Microbiology

Editorial Information

Last reviewed: 21/04/2026

Next review date: 21/04/2029