Warning

Clinical features

  • Headache – often severe and localised
  • Altered mental state
  • Focal neurological signs including diplopia
  • High fever
  • Nausea and vomiting
  • Seizures

Investigations

  • Blood culture
  • CT brain

Infection control

Nil specific

Treatment

Discuss with Neurosurgery

Discuss with Microbiology regarding antibiotic choice. CEFTRIAXONE is a restricted antimicrobial for this indication and you will need an authorisation code

CEFTRIAXONE (IV)  2g 12 hourly

Plus

METRONIDAZOLE (PO)  400mg 8 hourly (IV at 500mg 8 hourly if oral route is unavailable)

Editorial Information

Last reviewed: 21/04/2026

Next review date: 21/04/2029