NICE Clinical Knowledge Summaries - Impetigo

 

Impetigo is usually a self-limiting infection which usually heals in 1-3 weeks without treatment

Impetigo is usually a clinical diagnosis, and investigations are not routinely needed.

Do not take a swab unless there widespread infection or failure/recurrence despite appropriate hygiene measures and empirical treatment as below.

 

Preferred treatments:

Localized non-bullous impetigo and not systemically unwell or at risk of complications: Hydrogen peroxide 1% cream

H2O2 not suitable OR widespread non-bullous impetigo and not systemically unwell/at risk of complications: Topical Fusidic acid  (Mupirocin is another topical treatment option if suspected/confirmed Fusidic acid resistance)

Localised/widespread lesions but more systemically unwell OR bullous impetigo: Oral antibiotic

 

Adults and children aged 2 years or older with minor skin infection can be referred to their local community pharmacy for topical fusidic acid treatment.

 

Drug details

Hydrogen Peroxide 1% Cream

Apply TDS

5 days

Topical Fusidic Acid 2%

Apply TDS

5 days

Flucloxacillin

500mg QDS

Child

1 month to 1 year: 62.5mg to 125mg QDS

2 to 9 years: 125mg to 250mg QDS

10 to 17 years: 250mg to 500 mg QDS

5 days

Penicillin Allergy:

Doxycycline

 

200mg STAT then 100mg OD

 

5 days

Age <12yr old with

penicillin allergy:

Clarithromycin

 

 

Under 8 kg - 7.5mg/kg BD

8 to 11 kg - 62.5mg BD

12 to 19 kg: 125mg BD

20 to 29 kg - 187.5mg BD

30 to 40 kg - 250mg BD

 

 

 

5 days