Warning

CKS – see criteria for admission

For people with acute diverticulitis who are systemically well;

  • Consider a no antibiotic prescribing strategy
  • Offer simple analgesia, for example paracetamol
  • Advise the person to re-present if symptoms persist or worsen

Only offer an oral antibiotic to a person with acute diverticulitis if they are systemically unwell but do not meet the CKS criteria for referral for suspected complicated acute diverticulitis.

Drug details

Adults: First line

Co-trimoxazole 960mg twice daily for 5 days

+

Metronidazole 400mg three times daily for 5 days

 

Note: Co-trimoxazole is unlicensed for this indication but has been successfully used in Grampian for this indication for many years.

Children

Seek specialist advice

Editorial Information

Last reviewed: 27/11/2025

Next review date: 27/11/2028

Author(s): Antimicrobial Pharmacists.

Version: 1

Author email(s): gram.antibioticpharmacists@nhs.scot.

Approved By: Antimicrobial Management Team

Document Id: AMT_Emp_Primary Care_Diverticulitis_1