|
Step
|
Morning (mg) |
Night (mg) |
Total daily dose (diazepam mg)
|
| Starting dose |
Lorezapam 1 |
Lorezapam 1 |
20 |
| Step 1 |
Lorezapam 1 |
Diazepam 10 |
20 |
| Step 2 |
Diazepam 10 |
Diazepam 10 |
20 |
| Step 3 |
9 |
10 |
19 |
| Step 4 |
8 |
10 |
18 |
| Step 5 |
7 |
10 |
17 |
| Step 6 |
6 |
10 |
16 |
| Step 7 |
5 |
10 |
15 |
| Step 8 |
4 |
10 |
14 |
| Step 9 |
3 |
10 |
13 |
| Step 10 |
2 |
10 |
12 |
| Step 11 |
1 |
10 |
11 |
| Step 12 |
Stop |
10 |
10 |
| Step 13 |
- |
9 |
9 |
| Step 14 |
- |
8 |
8 |
| Step 15 |
- |
7 |
7 |
| Step 16 |
- |
6 |
6 |
| Step 17 |
- |
5 |
5 |
| Step 18 |
- |
4 |
4 |
| Step 19 |
- |
3 |
3 |
| Step 20 |
- |
2 |
2 |
| Step 21 |
- |
1 |
1 |
| Step 22 |
- |
Stop |
Stop |
Note: See approximate dose equivalents and switching considerations above. Lorazepam is more potent and has a shorter half-life than diazepam. Therefore, cross tapering may be appropriate as a first step to allow assessment of tolerance and adverse effects (e.g. sedation, withdrawal) prior to active reduction.