Warning

IV antibiotics administration

Prior to making up any antibiotics you need to check MEDUSA (NHS Injectable Medicines Guide).

This contains instructions on how to prepare and administer IV medication.

Go to the bottom of the intranet homepage

Screenshot of bottom of intranet homepage

Select Medusa Injectable Medicines Guide then click on homepage link

Screenshot of Homepage link

Alternatively, you can click here External website to link directly to Medusa Injectable Medicines Guide External website.

Select a route: IntraVENOUS

Screenshot of medusa's front page: Select route of drug to be given

Select a patient group: Click Adult

Screenshot of medusa: Select a patient group, adult or paediatric

Click: Continue to adult IntraVENOUS

Screenshot of medusa: Continue to adult IntraVenous

Search for drug and click magnifying glass, full drug name not required

Screenshot of Medusa: Example of searching for required drug, mero

Click on the required drug

Screenshot of Medusa: Example of search results

Follow 'Preparation and Administration' instructions

Screenshot of Medusa: Example of monograph for required drug

         

 

Commonly used IV antibiotics

Medication Indication Anything of note
IV Pipercillin Tazobactam (Taz) 1st line for new pyrexia

Broad spectrum antibiotic

Contains penicillin

IV Ceftazadime 1st line for new pyrexia if allergic to penicillin  
IV Aztreonam 1st line if severe allergy to penicillin  
IV Gentamicin    
IV Vancomycin    
IV Meropenem    
Metronidazole    

Further treatment guidance / reference documents:

More information can be found at Antimicrobial prescribing: NHS Lothian on the Right Decisions Service.

There are also the Lothian guidelines for febrile neutropenia and neutropenic sepsis External website [only accessible from an NHS Lothian device] and Antimicrobial Treatment Policy external website.

Gentamicin

Gentamicin is a broad spectrum antibiotic.

It is given to haematology patients if they are neutropenic septic.

Given to patients prior to catheter insertion if they are neutropenic.

Dosing is weight related, ensure your patient has an up to date weight.

Given once a day unless renal function impaired. Gentamicin dosing calculator works out the recommended frequency.

Check dose on dosing calculator and monitoring chart (specific to patient) and Hepma.

Levels must be taken to ensure gentamicin is at a therapeutic level.

Further treatment guidance / reference documents:

More information can be found at Gentamicin - how to use it well! on the Right Decisions Service.

Full guidance should always be accessed in conjunction with the information above, table should not be used in isolation.

Vancomycin

Vancomycin is an antibiotic used to treat a variety of bacterial infections.

Dosing is weight related, ensure your patient has an up to date weight.

Daily U&E’s to check creatinine clearance as vancomycin is eliminated via kidneys.

Check dose on form and HEPMA.

Levels must be taken to ensure vancomycin is at a therapeutic level.

Check dose on form and HEPMA.

Further treatment guidance / reference documents:

More information can be found at Vancomycin - adult intermittent infusion on the Right Decisions Service.

Full guidance should always be accessed in conjunction with the information above, table should not be used in isolation.

Commonly used oral antibiotics

Commonly Used Oral antibiotics within Edinburgh Cancer Centre (For IV antibiotics see Commonly used IV antibiotics, above)

  • Co-Amoxiclav
  • Co-trimoxazole
  • Ciprofloxacin
  • Clarithromycin
  • Doxycycline
  • Flucloxacillin

Further treatment guidance / reference documents:

Only accessible from an NHS Lothian Device:

Lothian guidelines for febrile neutropenia and neutropenic sepsis external website

Haematology Antimicrobial Treatment Policy External website

Editorial Information

Last reviewed: 09/02/2026

Next review date: 09/02/2027

Author(s): Lizi Trafford.

Version: Version 2

Approved By: Cancer Therapeutics Advisory Committee (CTAC)

Reviewer name(s): Lizi Trafford.