SACT regimens

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Common haematology SACT regimens

Please note that the table below may need to be scrolled horizontally or vertically in order to view all information, depending on your device.

Regime Drugs Indications
ABVD
  • Doxorubicin
  • Bleomycin
  • Vinblastine
  • Darcarbazine
 Hodgkin Lymphoma
Azacitidine
  • Azacitidine

Acute Myeloid Leukaemia

MDS - Myelodysplastic syndrome
BrECADD
  • Brentuximab
  • Etoposide
  • Cyclophosphamide
  • Doxorubicin
  • Dacarbazine
  • Dexamethasone

Advanced Stage Hodgkin Lymphoma
CEOP
  • Cyclophosphamide
  • Etoposide
  • Vincristine
  • Procarbazine
 Non Hodgkin Lymphoma
CHOP
  • Cyclophosphamide
  • Doxorubicin
  • Vincristine
  • Prednisolone
 Non Hodgkin Lymphoma
CODOX-M
  • Cyclophosphamide
  • Cytarabine
  • Vincristine
  • Prednisolone
  • Methotrexate

Inpatient Fluid balance (Same monitoring as high dose methotrexate)

 High-grade lymphomas: Burkitt's lymphoma DLBCL with adverse features
DA
  • Daunorubicin
  • Cytarabine
 Acute Myeloid Leukaemia
DBLd
  • Daratumumab
  • Bortezomib
  • Lenolidamide
  • Dexamethasone
 Newly diagnosed multiple myeloma 
Elranatamab
  • Elranatamab
 BiTE therapy (Bispecific T-cell engager) for Myeloma
Epcoritamab
  • Epcoritamab
 BiTE therapy (Bispecific T-cell engager) for Lymphoma
Escalated BEACOPDac
  • Bleomycin
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Vincristine
  • Prednisolone
  • Darcarbazine
  • Mesna
 Advanced stage Hodgkin Lymphoma where escalated therapy is indicated
FLAG-IDA
  • Fludarabine
  • Cytarabine
  • Granulocyte colony stimulating factor
  • Idarubicin
 Acute Myeloid Leukaemia
GD-Carbo
  • Gemcitabine
  • Dexamethasone
  • Carboplatin
 Lymphoma
GDP
  • Gemcitabine
  • Dexamethasone
  • Cisplatin
 Curative or salvage treatment before autologous stem cell transplant
High dose methotrexate
  • Methotrexate
 Acute Lymphoblastic Leukaemia, High Grade Lymphomas, Prophylaxis and treatment of CNS Lymphoma
IVAC
  • IVAC
  • Ifosfamide Etoposide
  • Cytarabine
 High Grade Lymphoma
IVE
  • Ifosfamide
  • Etoposide
  • Epirubicin
 Lymphoma
LEAM
  • Lomustine
  • Etoposide
  • Cytarabine
  • Melphalan
 Autologous Transplant conditioning for Lymphoma
Len/Dex
  • Lenolidamide
  • Dexamethasone
 Multiple Myeloma
MATRIX
  • Methotrexate
  • Cytarabine
  • Thiotepa
  • Rituximab
 CNS Lymphoma
Obinutuzumab and Bendamustine
  • Obinutuzumab
  • Bendamustine

High risk of reaction. Patient to be given pre meds

Follicular Lymphoma
Obinutuzumab and Venetoclax
  • Obinutuzumab
  • Venetoclax

Chronic Lymphocytic Leukaemia
R (Pre fix) Ritux
  • Rituximab

High risk of reaction. Patient to be given pre meds

When Rituximab is added to a regime it gets added as a pre fix e.g. R-CHOP
Venetoclax and Azacitidine
  • Venetoclax
  • Azacitidine

Acute Myeloid Leukaemia
Zometa
  • Zoledronic acid

Pre treatment dental assessment required

Myeloma

Common oncology SACT regimens

Please note that the table below may need to be scrolled horizontally or vertically in order to view all information, depending on your device.

Regime Drugs Indications
Atezolizumab Immunotherapy Lung
BEP
  • Bleomycin
  • Etoposide
  • Cisplatin
 Inpatient regime day 8 and day 15 outpatient.
Bev/Lonsurf
  • Bevacizumab
  • Lonsurf
 Colorectal
Capecitabine
  • Capecitabine
  • Breast
  • Colorectal
  • Upper GI
CAPOX
  • Capecitabine
  • Oxaliplatin
  • Colorectal
  • Upper GI
Caelyx
  • Liposomal
  • Doxorubicin
  • Ovarian
  • Sarcoma
Carbo/taxol
  • Carboplatin
  • Paclitaxel
  • Breast
  • Gynae
  • Lung
(Weekly) Carbo/Taxol/XRT
  • Carboplatin
  • Paclitaxel
  • Radiotherapy
 Lung
Cis/5FU
  • Cisplatin
  • Fluorouracil
  
Cis/Gem
  • Cisplatin
  • Gemcitabine
 Upper GI
Cis/Vin
  • Cisplatin
  • Vinorelbine
 Lung
Concurrent Cisplatin/XRT
  • Cisplatin and radiotherapy
  
Denosumab
  • Bisphosphanate (Strengthens and protect bones)
 Breast
Docetaxel and Pred
  • Docetaxel
  • Prednisolone
 Prostate
DPT
  • Doxetaxel
  • Pertuzumab
  • Trastuzumab
 Breast
EC
  • Epirubicin (DNA Binding drug)
  • Cyclophosphamide
 Breast
ENCO/CETUX
  • Encorafanib
  • Cetuximab
 BRAF mutation colorectal
FOLFIRINOX
  • Oxaliplatin
  • Irinotecan
  • 5fu IV bolus and pump
  • Folinic acid
  • Upper GI
  • Colorectal
Fulvestrant Given as two IM injections consecutively Breast
Gem
  • Gemcitabine
 Upper GI
Gem/Abraxane
  • Gemcitabine
  • Abraxane
 Upper GI
IPi/NIVO
  • Ipilimumab
  • Nivolumab
 Melanoma
Kadcyla
  • Kadcyla
 Breast
MAP
  • Methotrexate
  • Doxorubicin
  • Cisplatin
 Osteosarcoma
NabPaclitaxel
  • NabPaclitaxel

Used for patients who have a hypersensitive to paclitaxal

 Gynae
Nivolumab
  • Nivolumab
 Can be used for multiple sites
OXMDG
  • Oxaliplatin
  • Fluorouracil bolus then pump attached to CVAD for 48 hours
  • Folinic acid
 Colorectal
Paclitaxel
  • Paclitaxel

Can be given weekly as a single agent

 Breast, Gynae
PCV
  • Procarbazine
  • Vincristine
  • Lomustine (CCNU)
 Brain
Pem
  • Pemetrexed
 Lung
Pembrolizumab
  • Pembrolizumab
 Can be used for multiple sites
PPT
  • Paclitaxel
  • Pertuzamb and Trastuzumab
 Breast
PT (SC) Pertuzumab and Trastuzumab (Given as one subcut injection) Breast
SACITU Sacituzumab Breast