For all NHS Lothian Guidelines associated with SACT or SACT Toxicity please access these on OOQs via NHS Lothian Intranet
Guidelines Associated with SACT or SACT Toxicity 
Systemic anticancer treatment toxicity guidelines can also be found on the RDS: Systemic anticancer treatment toxicity | Right Decisions
All UKONS - Acute Oncology Initial Management Guidelines: https://www.ukacuteoncology.co.uk/download_file/view/356/208
Febrile neutropenia is an oncological/haematological emergency.
See guidelines and remember the golden hour.
Follow Sepsis 6, use order sets for bloods and haematology septic screen.
Febrile neutropenia guideline | Right Decisions
Febrile neutropenia | Right Decisions
Ukons Guidelines 2023. Guideline 12. Suspected Neutropenic Sepsis
This is the accidental administration of drugs into the extra vascular tissue instead of the vein.
This can happen via cannula or a CVAD.
Can occur during SACT infusion or present post infusion (delayed extravasation).
With certain SACT drugs this cause extensive damage to the surrounding tissue and may cause necrosis. This require immediate action.
Symptoms include swelling, burning/stinging, redness, pain, skin irritation and blistering at the cannula site.
Please follow the extravasation policy (accessible on NHS Lothian device).
SACT act as foreign substances which can induce hypersensitivity and anaphylactic reactions that range from mild cutaneous symptoms to severe respiratory distress and cardiovascular collapse.
A hypersensitivity reaction is defined as an exaggerated or inappropriate immune response that may be localised or systemic and results in local tissue injury or changes throughout the body in response to an antigen or foreign substance. This reaction can occur rapidly after exposure to an antigen or might take a long time to develop and manifest.
Anaphylaxis is an acute severe multi-system type I hypersensitivity allergic reaction, which has a rapid onset, and can often be life-threatening. It may be precipitated by many SACT agents.
Please see below for full guidelines:
https://g10804.ideagenqpulse.com/QPulseDocumentServiceECC/Documents.svc/documents/active/attachment?number=S%5cTox%5c31 [Access via Intranet]
Ukons Guidelines 2023. Guideline 1.Anaphylaxis/Allergic Reaction/Hpyersensitivity
Guidelines for the management of Systemic Anti-Cancer therapy (SACT*) induced hypersensitivity- Haematology addendum 
[opens a Word document]
Edinburgh Cancer Centre new nurse handbook