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  5. Anti-D Immunoglobulin Administration Following Potentially Sensitising Events and Routine Antenatal Anti-D Prophylaxis in RhD Negative Women (559)

Anti-D Immunoglobulin Administration Following Potentially Sensitising Events and Routine Antenatal Anti-D Prophylaxis in RhD Negative Women (559)

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The following guideline refers to non-sensitised D negative women in pregnancy. Women who are confirmed to have immune (allo) sensitisation do not require anti-D.

Adequate prophylaxis is effective in reducing the incidence of sensitisation.

Consent should be obtained before anti-D administration in all events.

An information document and green card should be given to woman following a D negative result at booking.

Access the full guidance here 

Editorial Information

Last reviewed: 05/09/2025

Next review date: 31/07/2030

Author(s): Julie Murphy.

Version: 5

Approved By: Maternity Governance Group

Document Id: 559

References
Evidence method

Use of Anti-D Immunoglobin for the Prevention of Haemolytic Disease of the Fetus and Newborn. British Society for Haematology  Jan2014, updated Nov 2023

Ectopic pregnancy and miscarriage: diagnosis and initial management. NICE guideline [NG126] Published date: 17 April 2019

Abortion care. NICE guideline [NG140] Published date: 25 September 2019