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  6. Intravesical Gentamicin for the management of resistant urinary tract infection in patients aged ≥ 18 years (1239)

Intravesical Gentamicin for the management of resistant urinary tract infection in patients aged ≥ 18 years (1239)

A guideline is intended to assist healthcare professionals in the choice of disease-specific treatments.

Clinical judgement should be exercised on the applicability of any guideline, influenced by individual patient characteristics. Clinicians should be mindful of the potential for harmful polypharmacy and increased susceptibility to adverse drug reactions in patients with multiple morbidities or frailty.

If, after discussion with the patient or carer, there are good reasons for not following a guideline, it is good practice to record these and communicate them to others involved in the care of the patient.

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Editorial Information

Last reviewed: 21/11/2025

Next review date: 31/08/2028

Author(s): Michael Palmer.

Version: 1

Author email(s): michael.palmer@nhs.scot.

Approved By: Antimicrobial Utilisation Committee

Document Id: 1239

References
  • Summary of Product Characteristics for SPC for Cidomycin 80mg/2ml Solution for Injection (gentamicin) SANOFI Last updated on eMC: Accessed via medicines.org.uk/emc (accessed 9.10.23)
  • SIGN 160 Management of suspected bacterial urinary tract infection in adults July 2006, Updated July 2012 available via Management of suspected bacterial lower urinary tract infection in adult women (sign.ac.uk)
  • European Association of Urology (EAU) guideline on urological infections ) available via http://uroweb.org/guideline/urological-infections/
  • Royal Devon and Exeter NHS Foundation Trust. Intravesical gentamicin guideline May 2011. Date Due for revision June 2012.
  • The use of intravesical gentamicin to treat recurrent urinary tract infections in lower urinary tract dysfunction. Abrams P., Hashim H., Tomson C., Macgowan A., Skews R., Warren K. Neurourology and Urodynamics. 36 (8) (pp 2109-2116), 2017.
  • Intravesical gentamicin for recurrent urinary tract infection in patients with intermittent bladder catheterisation. Van Nieuwkoop C., den Exter P.L., Elzevier H.W., den Hartigh J., van Dissel J.T. International Journal of Antimicrobial Agents 2010; 36 (6): 485-490.
  • Gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on intermittent catheterization. Cox L., He C., Bevins J., Clemens J.Q., Stoffel J.T., Cameron A.P. Canadian Urological Association Journal 2017; 11 (9): E350-E354.
  • McPhee S, Bekarma H, Meddings R, et al. Intravesical Gentamicin (IVG) installations improve QOL and reduce micro-organism resistance in patient with recurrent UTI’s. Abstract 109. International Continence Society Conference, Gothenburg 2019. Available from: https://www.ics.org/2019/abstract/109
  • NHS GGC ADTC. Medicines blog: Safe disposal of sharps waste in primary care. Last updated 26/07/23. Accessed via GGC Medicines: Safe disposal of sharps waste in primary care. Accessed 9.11.23