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  6. Acute wheeze in children 2 years and older: assessment and management (623)

Acute wheeze in children 2 years and older: assessment and management (623)

Warning

Objectives

This guidance replaces the previous guidelines "Acute asthma in children aged between 2 and 5 years" and "Acute asthma in children > 5 years"

Separate guidance is available for Acute asthma in children aged < 2 years.

November 2023: This guidance is currently under review as it has gone beyond the standard review date. It reflects best practice at the time of authorship / last review and remains safe for use. If there are any concerns regarding the content then please consult with senior clinical staff to confirm.

Initial assessment

Wheeze severity assessment

MILD
SpO2>92% 

AND

  • Normal mental state
  • Able to talk normally
  • Subtle or No ⇧ WOB
    (work of breathing)
    • No accessory muscle use or chest wall recession
  • No⇧ Heart Rate (HR) or ⇧ Respiratory Rate (RR)

 

MODERATE
SpO2>92%

AND

  • Normal mental state
  • Dyspnoea resulting in limitation of full sentences
  • Moderate ⇧ WOB
    • Moderate accessory muscle use & chest wall recession
  • HR - PEWS <2
  • RR - PEWS <2
  • PEF >50% of best or predicted

SEVERE
SpO2<92%

AND

  • Agitated/distressed state
  • Marked dyspnea resulting in <3 word sentences
  • Severe⇧ WOB
  • Marked accessory muscle use and chest wall recession
  • HR - PEWS >2
  • RR - PEWS >2
  • PEF 33-50% of best or predicted

LIFE THREATENING
SpO2<92%

AND

  • Confused / drowsy
  • Unable to talk due to dyspnoea
  • CYANOSED
  • MAXIMAL WOB
  • Beware exhaustion may = poor respiratory effort
  • SILENT CHEST (exclude upper airway obstruction)
  • PEF <33% of best or predicted

'Red Flag' features

  • Has the patient previously received IV therapy for wheeze management?

  • Has the patient been admitted to the PICU previously for respiratory illness?

If YES to any of the above then patient should be discussed with on call Paediatric Registrar prior to discharge.

Drugs

Salbutamol MDI + Spacer – Initial therapy = 10 puffs.  (100mcg per puff)

Oxygen – minimum 6 l/min via non-rebreather mask

Prednisolone

2 -4yrs       20mg OD

>5yrs      40mg OD

 

Nebulised medication for Severe Wheeze

2-4yrs  

Salbutamol 2.5mg
Ipratropium bromide 250mcg
Magnesium sulphate 154mg (2.5mls)

>5yrs 

Salbutamol 5mg
Ipratropium bromide 250mcg (>12yrs 500 mcg)
Magnesium sulphate 154mg (2.5mls)


IV MEDICATION
(To be prescribed as per the Escalation to IV therapy care pathway)

1. Magnesium sulphate injection

40mg/kg over 20 minutes (max 2gram)

2. Aminophylline 

Loading dose

 

5mg/kg* for all ages
(*unless on long-acting theophylline)

Continuous dose

<12 years 1mg/kg/hr 

≥12 years 500 mcg/kg/hr

3. Salbutamol

Bolus dose

Infusion dose

15µg/kg over 10mins

1-5µg/kg/min

- Hydrocortisone

- Ondansetron

4mg/kg QDS (max 100mg)

100micrograms/kg (max 4mg)

Discharge criteria and checklist

  • Patient maintaining saturations > 94% in air
  • Tolerating 3hrly multidosing        

Patients with MILD asthma at 1st assessment can be discharged after Salbutamol without being monitored for 4 hours

  • Discharge Checklist Completed
  • No red flag features
  • If presenting with interval symptoms medication reviewed and consideration given to starting Clenil Modulite 100mcg BD
  • Follow-Up arranged as below

Discharge planning - points to consider

Discharge Checklist Completed?
All the following must be completed prior to discharge

  • Inhaler technique checked
  • Asthma booklet given
  • Watched asthma education video
  • Completed 3 days prednisolone or remaining doses prescribed for home
  • Salbutamol inhaler (x2) and spacer dispensed
  • Wheeze plan given and explained
  • Parents advised what to do in event of clinical deterioration
  • Advised to attend GP within 48 hours discharge
  • Chronic features and criteria for follow-up reviewed
  • (Please document any follow-up requested)
  • Maintaining oxygen Saturations >/= 94% air
  • Tolerating 3hrly multi-dosing
  • Discharge Medication prescribed

Chronic features / Interval symptoms

If any of the following features:

  • 3 or more ED presentations with wheeze in 1 year
  • 3 or more courses of steroids for wheeze in 1 year
  • Answered yes to interval symptoms on wheeze proforma

AND not on a Preventer inhaler then prescribe Clenil modulite 100mcg BD

If already on a preventive inhaler review compliance and criteria for follow-up to assess need for hospital outpatient based follow up.

Criteria for Acute Medical Paediatric Follow Up

GP’s should be able to manage the majority of children with wheeze

Patients who have been started on a clenil inhaler should be advised to attend their G.P. in 6 weeks to assess response.

Children where there is diagnostic uncertainty or very young children (between the ages of 2 and 3) with concern about recurrent presentations then discuss Follow up planning with either the general paediatrician or senior paediatric registrar on tel: 84678.

Criteria for Respiratory Team Follow Up

Any child requiring intravenous therapy for wheeze.

Patients who have required intravenous therapy for wheeze should be monitored in hospital for at least 24 hours post the discontinuation of all intravenous therapy.

Any child where there is a concern that they have failed to respond to significant asthma treatment.

ALL RESPIRATORY REFERRALS SHOULD BE DISCUSSED WITH RESPIRATORY TEAM PRIOR TO PATIENT DISCHARGE FROM HOSPITAL.

Escalation to intravenous therapy for acute wheeze integrated care pathway (ICP) - for patients over 2 years old

Editorial Information

Last reviewed: 16/10/2025

Next review date: 31/07/2026

Author(s): Dr Steve Foster (Consultant in Paediatric Emergency – Paediatric Emergency Department), Dr Morag Wilson (Consultant in General Paediatrics – Acute Paediatrics).

Version: 2

Approved By: Clinical Effectiveness

Document Id: 623

References
  1. BTS/SIGN British guideline on the management of Asthma; 2019.
  2. Mechanism of lactic acidosis in children with acute severe asthma; Meert KL, McCaulley L, Sarnaik AP. Paediatric Critical Care Medicine. 2012 Jan;13(1):28-31
  3. A Clinical Guideline for the use of Aminophylline in Acute Severe Asthma in Children; Norfolk and Norwich University Trust. Dr Caroline Kavanagh; 5th April 2017
  4. Aminophylline Dosage in Children Asthma Exacerbations in Children: A Systematic Review; Cooney L, Sinha I, Hawcutt D. PLoS One. 2016.
  5. Standards for Level of Asthma Intervention; Greater Glasgow and Clyde Health Board
  6. Aminophylline Hydrate; December 2015.
  7. BNF for Children. Aminophylline.
  8. BNF for Children. Hydrocortisone
  9. BNF for Children. Prescribing for children: weight, height and gender.
  10. Clinical Practice Guidelines: Asthma Acute. The Royal Hospital for Children, Melbourne. May 2015