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HIV Pre-exposure Prophylaxis (PrEP) (1257)

A guideline is intended to assist healthcare professionals in the choice of disease-specific treatments.

Clinical judgement should be exercised on the applicability of any guideline, influenced by individual patient characteristics. Clinicians should be mindful of the potential for harmful polypharmacy and increased susceptibility to adverse drug reactions in patients with multiple morbidities or frailty.

If, after discussion with the patient or carer, there are good reasons for not following a guideline, it is good practice to record these and communicate them to others involved in the care of the patient.

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Editorial Information

Last reviewed: 22/01/2026

Next review date: 30/09/2026

Author(s): Kay McAllister.

Version: 1

Author email(s): kay.mcallister2@nhs.scot.

Approved By: Sandyford Governance Group

Document Id: 1257

References

References and further information

British HIV Association and British Association of Sexual Health and HIV. BHIVA/BASHH guidelines on the use of HIV pre-exposure prophylaxis (PrEP) 2025

Available at: BASHH/BHIVA guidelines on the use of HIV pre-exposure prophylaxis (PrEP) 2025 – BHIVA  [accessed 26/08/2025]

McCormack S et al; Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial Lancet 2016; 387: 53–60

Molina JM et al. On-Demand Pre-exposure Prophylaxis in Men at High Risk for HIV-1 Infection.  N Engl J Med 2015; 373:2237-2246

Eligibility criteria for Tenofovir AF/Emtricitabine (Descovy®) for Pre-exposure Prophylaxis for HIV (PrEP) in Scotland 2022