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Syphilis (1245)

A guideline is intended to assist healthcare professionals in the choice of disease-specific treatments.

Clinical judgement should be exercised on the applicability of any guideline, influenced by individual patient characteristics. Clinicians should be mindful of the potential for harmful polypharmacy and increased susceptibility to adverse drug reactions in patients with multiple morbidities or frailty.

If, after discussion with the patient or carer, there are good reasons for not following a guideline, it is good practice to record these and communicate them to others involved in the care of the patient.

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Editorial Information

Last reviewed: 20/03/2026

Next review date: 31/12/2027

Author(s): Kay McAllister.

Version: 2

Author email(s): kay.mcallister2@nhs.scot.

Approved By: Sandyford Governance Group

Document Id: 1245

References

BASHH UK guidelines for the management of syphilis 2024 accessed via https://www.bashh.org/resources/25/syphilis_2024_updated_guideline  [Accessed 19/11/2025

2020 European guideline on the management of Syphilis.  Accessed via 2020-Syphilis-guideline.pdf [Accessed 19/11/2025]

Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2021. Syphilis.  https://www.cdc.gov/std/treatment-guidelines/syphilis.htm   [Accessed 19/11/2025]