Switching ART regimens and use of single tablet regimens (STR)

Some single tablet regimens (STR) are significantly more expensive than either alternative single tablet regimens or disaggregation from a single tablet regimen to a two or three pill combination. Disaggregation can release savings from STRs using alternative generic and branded versions of their constituent parts or using suitable alternatives, including consideration of dual therapy. Given the regular change to pricing, and the likely availability of further generic drugs in the future, prescribers should have an awareness that some treatment options may offer now and in the future significant cost reductions and that patients are often willing to consider alternatives based on cost alone. Additional monitoring, healthcare team and patient time may be required in the short term to ensure supported changes are made safely and effectively.

The HIV Clinical Leads supports the review of patients on single tablet regimens and other co-formulated medication to maximise the opportunity to recognise cost savings. However, patient views and outcomes are integral to such decisions.