Surplus medication supply may accumulate for numerous reasons, such as changes in appointment dates or therapy switches. Adherence support and patient feedback on dispensed medication is an integral part of clinical care. Peer support and the third sector can help patients optimise dealing with medication supplies in long term conditions such as HIV. Clinical teams and Pharmacy staff can have an impact on reducing drug wastage by ensuring that only the required amount of medication is dispensed and that the timing of elective therapy switches are carefully planned. In some NHS Boards, electronic prescriptions and utilising homecare company deliveries have assisted this function. Waste minimisation however must be balanced by ensuring treatment access and adherence.