Sepsis in immunocompromised child

Review previous microbiology results: If resistant target organisms previously isolated (e.g. MRSA, ESBL, known resistance to empirical antibiotic choices), discuss antibiotic choice with Paediatric and/or Microbiology Consultant.

User guide: for further advice regarding antimicrobial prescribing good practice, oral switch, penicillin allergy, dosing, and safety considerations: HERE

First line

IV piperacillin/tazobactam
and IV gentamicin

Suspected staphylococcal infection (e.g. line-related sepsis, skin/soft tissue infection) OR known MRSA positive:
add IV vancomycin / IV teicoplanin

Penicillin allergy

IV vancomycin
and IV gentamicin

TOTAL duration

With clinical improvement, and on advice from Paediatric Consultant and/or Microbiology Consultant.

Comments

If haematology/oncology patient, discuss with appropriate specialist and seek local microbiology advice.
If patient known to Schiehallion, refer to Schiehallion neutropenia and fever policy: HERE

Last reviewed: 20/02/2024

Next review date: 20/02/2026

Author(s): Dr Jon van Aartsen (Consultant Microbiologist), Dr Jed Bamber (Consultant Paediatrician).

Version: v1.0

Approved By: AMT (20.02.2024) and ADTC (28.02.2024)

Reviewer name(s): Dr Jed Bamber (Consultant Paediatrician), AMS Team.

Sepsis in immunocompromised child

Editorial Information