Table 1: Risk stratification for breast cancer

• Equates to 17% or less lifetime risk

• Equates to a lifetime risk of breast cancer of greater than 17% but less than 30%, 
• or a 10-year risk between 40 and 50 years of age which is greater than 3% but less than 8% 

• Equates to a lifetime risk of developing breast cancer of 30% or more, 
• or greater than 8% 10-year risk between 40 and 50 years of age 

• Equates to a lifetime risk of developing breast cancer of 40% or more, 
• Equates to a woman in her thirties whose 10-year risk is greater than 8% as assessed at age 30, 
• or in her forties and whose 10-year risk is greater than 20% as assessed at age 40. 

• Anyone not fulfilling moderate, high or very high risk criteria

• One first-degree* relative with breast cancer diagnosed under the age of 40, or one first-degree relative with male breast cancer diagnosed at any age, 
• or two first- or one first- and one second-degree relative with breast cancer any age, or ovarian cancer at any age, on the same side of the family, 
• or three first- or second-degree relatives with breast or ovarian cancer on the same side of the family where one is a first-degree relative of the individual under review or of their father 

A case of bilateral breast cancer should be treated as the equivalent of 2 affected relatives. 

• families where there is an estimated 20% likelihood of a BRCA1, BRCA2 or TP53 mutation 

The individual being assessed should be a first-degree relative of an affected family member or a second-degree relative through an unaffected male. 

Affected individuals should be first- degree relatives of each other or related through unaffected males. 

• Heterozygous carrier of a mutation in BRCA1, BRCA2, PALB2, STK11, PTEN and CDH1. 
• Heterozygous carrier of c.7271T>G ATM 
• Homozygous mutations in ATM, CHEK2 
• or woman at 30% or greater risk of carrying a mutation in a high-risk gene 

• Carrier of a mutation in TP53, 
• or woman at 30% or greater risk of carrying a mutation in TP53