Contraindications?

Symptoms beginning more than 4 ½ hours prior to infusion.

Known history of or suggested intracranial haemorrhage.

Symptoms suggestive of subarachnoid haemorrhage, even if CT-scan is normal.

Evidence of intracranial haemorrhage (ICH) on the CT-scan.

Manifest or recent severe or dangerous bleeding.

Known Haemorrhagic diathesis.

Systolic blood pressure above 185 or diastolic BP above 110mm hg and unable to get below this threshold within 4.5 hours of symptom onset.

None of the above.