Standard serology testing for coeliac disease in NHS Lothian

Coeliac serology testing (a coeliac screen, TTG IgA) is standard practice in symptomatic patients suspected to have the condition in gluten exposed individuals. If a patient is symptomatic, testing at any age over 6 months may be helpful. If asymptomatic, screening should not be carried out before the age of 12 months of age. Coeliac serology is a venous blood test (serum, gel tube 1mL minimum) processed at the WGH Biochemistry labs. In Lothian a total IgA measurement does not need to be requested routinely in addition as total IgA is automatically performed if the TTG IgA is below 0.6 U/mL. A TTG IgG will then be measured if the total IgA level is below 0.2 g/L. In Lothian, the normal range for coeliac serology (Lothian assay is Orgentec ®, Mainz, Germany) is 0.1 to 5.0 U/mL.