Metformin, sulfonylureas, glitazones

Polypharmacy guidance: realistic prescribing
Scottish Government Effective Prescribing & Therapeutics Division
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Chapter 6: Endocrine system

  • CAUTION: Risk of lactic acidosis. Avoid if eGFR < 30 ml/min. Stop when at risk of dehydration
  • CAUTION: Hypoglycaemia: Active metabolites can accumulate when renal function is impaired
  • Avoid in patients with heart failure