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OA at the base of the thumb or the 1st carpometacarpal joint occurs as a result of degenerative changes in the trapeziometacarpal joint. Its prevalence increases with age, studies showing it can affect 15% of the population, and is more common in postmenopausal women. Patients often present with radial sided wrist pain, weakness and grating or crepitus at the base of the thumb. Symptoms are worsened by activities involving the thumb such as pinching and gripping.
