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Gynaecomastia

Warning

The Gynaecomastia pathway includes recommendations for management in primary care and in the breast unit.

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Background

Definition: Gynaecomastia is a benign enlargement of the male breast with firm tissue extending concentrically beyond the nipple. It may unilateral, bi-lateral, painful or asymptomatic4.

Overview

The Modernising Patient Pathway Programme (MPPP) Symptomatic Breast Specialty Delivery Group (SDG) has been established to support and explore innovative approaches to the delivery of symptomatic breast services across NHS Scotland.

Through the development of Once for Scotland approaches to delivery of patient care, there is a strong focus on identifying opportunities to further develop clinical pathways. This aims to reduce unwarranted variation in the quality of care and to improve waiting times for non-urgent breast services. Specialty Delivery Groups play a key role in this work by engaging clinical leadership and fully utilising their roles across NHS Scotland.

The development of a Gynaecomastia Pathway has been progressed through the MPPP SDG, reflecting a common theme identified during engagement with colleagues across NHS Scotland.

The recommendations outlined have not followed the standard SIGN development process and are instead based on available guidance and expert consensus. Peer review has also been undertaken to provide appropriate quality assurance.

This guidance will be reviewed and updated as new evidence emerges.

Consensus

A common theme during the Breast Speciality Delivery group meetings has focused on the referral of men with breast issues to secondary care services.

A consensus was formed around the principles that:

  • Gynaecomastia is a breast manifestation of a systemic problem. Secondary care referral and investigation is not necessary in the vast majority of cases and variation in practice and over investigation are common.
  • Breast lumps in men (rather than generalised swelling of the breast tissue) require specific investigation.

Patient Guidance

The Breast Services pathways for Scotland seek to promote equitable, safe, and timely access to assessment and care for all patients presenting with breast related symptoms, including breast pain, nipple discharge, axillary or skin lumps, and gynaecomastia. Pathway access and clinical decision‑making should be based on the presenting symptom, underlying breast tissue, and individual clinical risk, ensuring that no patient is unintentionally disadvantaged.

These symptomatic pathways apply to all patients, including trans and gender‑diverse individuals. Referral, investigation, and management should be guided by the nature of the presenting symptom, relevant anatomy, prior medical or surgical history (including any gender-affirming treatment), and clinical risk factors, rather than gender identity alone. The aim is to ensure that patients with breast symptoms are directed to the most appropriate diagnostic pathway without delay.

Patients who have residual breast tissue, regardless of gender identity, should be referred through standard symptomatic breast pathways when they present with breast symptoms. Those who have had chest or breast surgery may still require referral if symptoms arise in remaining breast tissue, the chest wall, axilla, or skin.

In light of the Supreme Court ruling on the definition of biological sex within the Equality Act 2010, services should recognise that biological sex may remain a relevant determinant for certain aspects of investigation, clinical management, or accommodation within breast services. Where this is the case, any alternative arrangements should be proportionate, clinically justified, and handled sensitively, ensuring patient dignity while maintaining safety and pathway clarity.

Pathway Recommendations: Management within Primary Care

Breast Examination

Should distinguish between general swelling of the breast tissue or a specific lump. Swelling of breast tissue due to gynaecomastia is often asymmetrical. A soft, well-defined lump away from the breast tissue is likely to be a lipoma and may not require further investigation, especially if other lipomas are present. A specific lump within the breast tissue (rather than generalised breast swelling) or other features of concern (such as nipple inversion, nipple discharge or distortion) requires referral to the breast unit.

Testicular Examination

Testicular examination should routinely be included as part of the assessment process in Primary Care. 

Patient History

Should be taken for causes of gynaecomastia, including drugs (prescribed or otherwise), alcohol, protein supplements, liver disease, testicular issues and obesity (see Systemic conditions associated with gynaecomastia). In those going through puberty or the very old, gynaecomastia is likely to be due to normal, age-related hormonal changes. Drugs causing gynaecomastia include antioestrogens, spironolactone, calcium channel blockers, proton pump inhibitors, cimetidine, allopurinol, digoxin, opioids, anabolic steroids and cannabis. The use of protein supplements also appears to be associated. Testicular examination should be performed for atrophy, absence or lump. If any predisposing cause is identified this should be addressed. Gynaecomastia is likely to persist or recur after treatment if the underlying cause is still present. Pubertal gynaecomastia will usually resolve spontaneously but can take many months.

Blood Tests

In the absence of a predisposing cause, consider blood tests for urea and electrolytes, liver function tests, Luteinizing hormone, Follicle Stimulating Hormone testosterone, prolactin, beta human chorionic gonadotropin- and alpha-fetoprotein and thyroid function tests and address any abnormalities.

Medical Treatment

Consider medical treatment for persisting pubertal gynaecomastia or where there is no obvious predisposing cause or abnormality of blood tests. This is an unlicensed indication. It is most useful for recent onset gynaecomastia and usually improves breast sensitivity. If prescription of a medication out with it's licensed indication is being considered discussion with secondary care colleagues is an option should this be felt necessary for the small number of patients who may benefit.

  • Tamoxifen 10mg once daily for 3-9 months
  • Anastrozole 1mg daily for 3 months

Surgical Excision

For cosmesis is considered through the exceptional aesthetic referral pathway.

Pathway Recommendations: Management within Breast Units

  • Those with a breast lump (not just generalised breast swelling) should undergo triple assessment. Those with a clinically obvious lipoma may not need further investigation.
  • Investigation and treatment pathways are otherwise as noted above for primary care.
  • When an obvious cause of gynecomastia is present, further investigation is not necessary.
  • Consider mammography in those over 40. Ultrasound scanning is not required unless a specific breast lump (not just generalised breast swelling or a lipoma) is present.

Systemic Conditions Associated with Gynaecomastia

  • Testicular failure
  • Liver disease
  • Obesity
  • Renal failure
  • Adrenal disease
  • Hyperthyroidism
  • Testicular cancer
  • Lung cancer
  • Klinefelter’s syndrome

 

References and Further References

 

1. Association of Breast Surgery. Investigation and management of gynaecomastia in primary and secondary care [Internet]. 2021 [cited 2026 May]. Available from:             https://associationofbreastsurgery.org.uk/media/b2ljdqhr/abs-summary-statement-gynaecomastia-v3.pdf

2. Royal College of Radiologists. Guidance on screening and symptomatic breast imaging. 5th ed. [Internet]. London: RCR; 2025 [cited 2026 May]. Available from: https://www.rcr.ac.uk/our-services/all-our-publications/clinical-radiology-publications/guidance-on-screening-and-symptomatic-breast-imaging-fifth-edition/ 

3. BMJ Best Practice. Gynaecomastia [Internet]. 2026 [cited 2026 May]. Available from: https://bestpractice.bmj.com/topics/en-gb/869

4. NHS Scotland (Right Decisions). Gynaecomastia pathway [Internet]. 2023–2026 [cited 2026 May]. Available from: https://www.rightdecisions.scot.nhs.uk/breast-pathways/gynaecomastia/ 

 

 

 

 

   gjnh.cfsdpmo@gjnh.scot.nhs.uk

  www.nhscfsd.co.uk

@NHSScotCfSD

Centre for Sustainable Delivery

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Editorial Information

Last reviewed: 22/07/2026

Next review date: 04/06/2029

Author(s): Symptomatic Breast Specialty Delivery Group.

Version: 2.0

Approved By: Centre for Sustainable Delivery

Reviewer name(s): Centre for Sustainable Delivery.