03/10/25 (V2):
25/09/25: Added: 'Procyclidine solution for injection 10mg/2mL, there is a known shortage with this product see: Medicines shortage log (NHS Highland intranet access required)' (Removed 03/10/25)
Antimuscarinic drugs reduce the symptoms of drug-induced Parkinsonism, although tardive dyskinesia is not improved and may be worsened. They do not improve akathisia unless associated with stiffness. Assess the need for antimuscarinic drugs after 3 months of treatment. These drugs have the potential for misuse and careful review of some patients’ motivation in asking for them is required. Antimuscarinic drugs are known to have an effect on cognition, particularly in the elderly.
For the treatment of acute dystonic reactions and oculogyric crisis see: Rapid tranquilisation (Guidelines) | Right Decisions for alternative anticholinergic injection choices.
Tablets 5mg
As per:
Older people, preferably lower end of range. When stopping reduce stepwise to the minimum effective dose.
Syrup 2·5mg/5mL
As per:
Older people, preferably lower end of range. When stopping reduce stepwise to the minimum effective dose.
TAM (Treatments and Medicines) NHS Highland