First line management
- First choice is metformin. If GI disturbance, metformin MR.
- Lifestyle management including diet, weight management and physical exercise should be an ongoing consideration at all stages.
- If required short-term, rescue therapy for symptomatic hyperglycaemia - sulphonylurea, insulin.
Is there existing ASCVD, HF, CKD?
Second line therapy aims: improvement in cardiorenal outcomes, achievement of target